Detection of immunoreactive interleukin-11 in human follicular fluid: correlations with ovarian steroid, insulin-like growth factor I levels, and follicular maturity.
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CONTRIBUTORS:
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JOURNAL:
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Fertility and Sterility,
67(6),
1054 -
1058.
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YEAR:
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1997
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PUB TYPE:
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Journal Article
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SUBJECT(S):
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None
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DISCIPLINE:
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Medicine
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HTTP:
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LANGUAGE:
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English
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PUB ID:
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103-483-586
(Last edited on
2010/11/07 07:36:51 US/Mountain)
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SPONSOR(S):
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ABSTRACT:
OBJECTIVE: To prove the presence of interleukin-11 (IL-11) in the follicular fluid (FF), to determine its source and the correlation between IL-11 and fertilization outcome, follicular size, number of follicles per patient, steroids, and insulin-like growth factor-1 (IGF-I) levels.
DESIGN: Interleukin-11 levels were measured in FFs, aspirated during oocyte pickup for IVF.
SETTING: Academic hospital and research environment.
PATIENT(S): Follicular fluid and serum were obtained with informed consent from 44 patients undergoing IVF-ET. Granulosa cells were isolated from 17 patients.
MAIN OUTCOME MEASURE(S): We hypothesized that IL-11 might play a role in follicular development, as do other related cytokines present in FF. Interleukin-11 was measured with ELISA.
RESULT(S): Interleukin-11 was absent in the serum but present in FF and in conditioned medium from granulosa cells. Atretic follicles had higher concentrations of IL-11. No correlation was found between IL-11 and fertilization outcome, follicular size, steroid, IGF-I, and total protein concentrations.
CONCLUSION(S): We conclude that IL-11 is present in FF. The role of IL-11 in follicular development should be the object of further investigations.
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