Formulation and Evaluation of Glimepiride Solid Dispersion Tablets
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CONTRIBUTORS:
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JOURNAL:
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Asian Journal Of Pharmaceutics,
4(3),
212 -
218.
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YEAR:
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2010
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PUB TYPE:
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Journal Article
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SUBJECT(S):
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None
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DISCIPLINE:
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Pharmacy
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HTTP:
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LANGUAGE:
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English
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PUB ID:
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103-483-463
(Last edited on
2011/02/17 00:53:58 US/Mountain)
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SPONSOR(S):
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ABSTRACT:
Since Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for oral bioavailability of Glimepiride. An attempt has been made to increase the solubility of this model drug by formulating solid dispersion using Poloxamer 188 (PXM 188) as polymer and then formulating solid dispersions tablets of the best formulation of solid dispersions. Tablets formulations were prepared by direct compression technique using superdisintegrant crosccarmellose sodium in different concentrations. Solid dispersions were evaluated for XRD, SEM, iv vitro dissolution profiles and dissolution efficiency, and developed tablet formulations were evaluated for various pharmaceutical characteristics viz. hardness, % friability, weight variation, drug content, disintegration time, in vitro dissolution profiles and dissolution efficiency. Amongst different formulations of solid dispersions, solid dispersion containing drug is to polymer ratio 1:4 gives best dissolution profile and dissolution efficiency and amongst tablet formulations, formulations containing 5% crosccarmellose sodium gives best disintegration and dissolution profiles compared to other formulations. Results showed that poloxamer is a promising polymer for enhancing the solubility of GMP.
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