P. Revathi et al. (2010) Reproductive toxicity of Capparis aphylla (Roth.) in male albino rats

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Reproductive toxicity of Capparis aphylla (Roth.) in male albino rats

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CONTRIBUTORS:

	Author:	P. Revathi
	Author:	B. Vani
	Author:	I. Sarathchandiran
	Author:	B. Kadalmani
	Author:	K. Prakash Shyam
	Author:	K. Palnivel

JOURNAL:

International Journal of Pharmaceutical and Biomedical Research, 01(03), 102 - 112.

YEAR:

2010

PUB TYPE:

Journal Article

SUBJECT(S):

Pharmaceutical sciences, pharmaceutics, pharmacy, biomedical sciences, therapeutics

DISCIPLINE:

Pharmacy

HTTP:

http://www.pharmscidirect.com/Docs/IJPBR-2010-03-21.pdf

LANGUAGE:

English

PUB ID:

103-482-830 (Last edited on 2010/09/26 16:06:23 GMT-6)

SPONSOR(S):

ABSTRACT:
The present study reflects the effect of ethanolic extract of Capparis aphylla (Roth.) on male reproduction and fertility in adult albino rat. The result revealed that the administration of whole plant ethanolic extract of C. aphylla manifested an antifertility effect on male reproductive system. The complete loss of fertility is attributed to decline in epididymal sperm counts and motility as well as origin of bi- and multinucleate giant cells in the ad luminal compartment of the testis was observed. The administration of ethanolic extract at varied doses led to alteration in both the histoarchitecture of testis, mainly caput epididymis and erratic spermatogenesis have been documented. The data revealed that functional sterility could be induced in male rats by whole plant ethanolic extract treatment, which promises to be a potential male contraceptive.

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