Y.V. Kishore Reddy et al. (2010) Cisplatin and carboplatin induced changes in oxidative enzyme activity levels in albino rat’s liver

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Cisplatin and carboplatin induced changes in oxidative enzyme activity levels in albino rat’s liver

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CONTRIBUTORS:

	Author:	Y.V. Kishore Reddy
	Author:	P. Sreenivasula Reddy
	Author:	M.R. Shivalingam
	Author:	B. Appa Rao
	Author:	K. Sindhura
	Author:	G. Vasavya Sindhu
	Author:	M. Vijay Bhaskar Reddy

JOURNAL:

International Journal of Pharmaceutical and Biomedical Research, 01(03), 94 - 97.

YEAR:

2010

PUB TYPE:

Journal Article

SUBJECT(S):

Pharmaceutical sciences, pharmaceutics, pharmacy, biomedical sciences, therapeutics

DISCIPLINE:

Pharmacy

HTTP:

http://www.pharmscidirect.com/Docs/IJPBR-2010-03-19.pdf

LANGUAGE:

English

PUB ID:

103-482-828 (Last edited on 2010/09/26 15:59:07 GMT-6)

SPONSOR(S):

ABSTRACT:
The present study aimed to investigate the possible interference of cisplatin or carboplatin on oxidative enzymes in liver of albino rats. Rats were divided into three groups each consisting of eight animals. Group 1 (Control) received 0.9% of normal saline. Group 2 (Treatment) received cisplatin of 3 mg/kg body weight and Group 3 (Treatment) received carboplatin of 10 mg/kg body weight. Injections were given intra-peritoneally to rats on 1st, 3rd and 5th day of experimentation. On 45th day of experiment, animals were sacrificed by cervical dislocation. Succinate dehydrogenases (SDH), Lactate dehydrogenase (LDH), Glucose-6-phosphate dehydrogenase (G-6-PDH) activities in the cytosol fraction were assayed in liver of albino rats. Cisplatin or carboplatin treatment caused significant changes in activity levels of SDH, LDH & G-6-PDH in liver of experimental rats, when compared to control rats. From the study it may be concluded that, hepatic tissue is meeting its energy requirements through alternative pathways. In other words this can be viewed as functional or physiological adaptation of the liver in treated rats, may be due to stress caused by platinum-based anticancer drugs.

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