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ABSTRACT:
Abstract
Background: Obesity, metabolic syndrome, and atherosclerosis are linked with an increased acute-phase
response. Severe periodontal disease is associated with cardiovascular disease as sequelae of a systemic inflammatory response.
Objective: The aim of this study was to assess changes in measures of systemic inflammation induced by periodontal
therapy in periodontally diseased individuals with metabolic syndrome, compared to those induced in
a systemically healthy group.
Methods: A total of 31 subjects with chronic generalized periodontitis, including 16 subjects with metabolic
syndrome (group A) and 15 systemically healthy subjects (group B), underwent nonsurgical periodontal therapy.
Serum high-sensitivity C-reactive protein (hsCRP), total leukocyte count, and measures of lipid metabolism
were measured at baseline and at 2 months after periodontal therapy. Baseline data for comparison was also
obtained from 15 systemically and periodontally healthy individuals (group C).
Results: Baseline periodontal parameters and serum CRP were signifi cantly higher in group A than in group
B. In group A, following periodontal therapy, a signifi cant decrease was noted in mean serum CRP (3.28 ±
1.4 mg/L to 2.6 ± 1.5 mg/L), total leukocyte counts (8,322 ± 1,888 cells/mm 3 to 6,361 ± 1,426 cells/mm 3 ), serum
triglycerides (153.3 ± 38 mg/dL to 121.0 ± 28.57mg/dL), along with a signifi cant rise in serum high-density
lipoprotein (HDL) (41.1 ± 5.2 mg/dL to 44.37 ± 6.7 mg/dL). In group B, changes in these parameters were not
statistically signifi cant. Mean serum low-density lipoprotein (LDL) and mean cholesterol levels did not change
signifi cantly in either group.
Conclusions: Periodontal therapy produced signifi cant modulation of serum hsCRP, total leukocyte, serum triglycerides,and HDL, and thus may benefi t individuals affected with both metabolic syndrome and advanced
periodontal disease.
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STATISTICS
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