Central corneal thickness measurements with optical coherence tomography and ultrasound pachymetry in healthy subjects and in patients after photorefractive keratectomy
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CONTRIBUTORS:
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JOURNAL:
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European Journal of Ophthalmology,
??(??),
?? - ??.
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YEAR:
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2008
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PUB TYPE:
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Journal Article
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SUBJECT(S):
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Central corneal thickness, pachymetry, Optical coherence tomography, photorefractive keratectomy
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DISCIPLINE:
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Engineering and Applied Sciences
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HTTP:
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LANGUAGE:
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English
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PUB ID:
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103-444-578
(Last edited on
2009/11/23 19:54:07 US/Mountain)
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SPONSOR(S):
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ABSTRACT:
Purpose: To compare central corneal thickness measurements made using two different methods, optical coherence tomography (OCT) and ultrasound pachymetry, applied both in normal eyes and in eyes on which photorefractive keratectomy (PRK) had been performed. A second objective was to assess the intrasession variability of OCT measurements.
Subjects and methods: In this prospective study, central corneal thickness was measured in 20 normal subjects (normal group) and in 20 PRK patients using the StratusOCT instrument model 3000 (Carl Zeiss Meditec), and also with an ultrasound pachymeter. Five OCT measurements were performed using the Fast Macular Thickness protocol. Corneal thickness data was obtained with the Scan Profile analysis protocol. The OCT measurement results were compared with the mean value of 3 ultrasound pachymetry measurements for the same eye.
Results: The pachymetry – OCT correlation coefficients were 0.96 and 0.97 in the normal and PRK groups, respectively (p=0.14). Neither linear regression nor Bland-Altmann analysis did reveal any significant systematic measurement error. Intrasession standard deviations in the normal and PRK groups were 4.9 μm and 3.8 μm, respectively.
Conclusion: Non-contact central corneal thickness measurements made using the StratusOCT instrument are accurate and reproducible, both in normal subjects and in post-PRK patients. The instrument system does not need any modifications to correctly detect and measure the centre of the cornea.
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