Evans et al. (2003) Frequency-dependent regulation of afferent transmission in the feeding circuitry of Aplysia

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Frequency-dependent regulation of afferent transmission in the feeding circuitry of Aplysia

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CONTRIBUTORS:

	Author:	Evans, Colin
	Author:	Jing, J.
	Author:	Proekt, Alexander
	Author:	Brembs, Björn (Freie Universität Berlin)
	Author:	Rosen, S.
	Author:	Cropper, Elizabeth

CONFERENCE NAME:

Annual Meeting of the Society for Neuroscience

CONF. LOCATION:

Washington DC

CONFERENCE YEAR:

2003

PUB TYPE:

Conference Presentation

SUBJECT(S):

Neurosciene, neurophysiology

DISCIPLINE:

Biology

HTTP:

http://sfn.scholarone.com/itin2003/main.html?new_page_id=126&abstract_id=3852&p_num=604.1&is_tech=0

LANGUAGE:

English

PUB ID:

103-425-992 (Last edited on 2006/04/13 05:27:32 GMT-6)

SPONSOR(S):

ABSTRACT:
One well-characterized mechanism that can regulate (or gate) afferent transmission consists of a synaptically induced conductance increase, which can gate-out afferent activity. We have identified a similar mechanism in the feeding circuitry of Aplysia. In our system the B4/5 neurons inhibit afferent transmission between the radula mechanoafferent B21 and one of B21s follower neurons, the radula closer motor neuron B8. We now demonstrate that effects of the B4/5 neurons on afferent transmission are frequency-dependent, and are in part determined by the membrane potential of B21 (depolarization in B21 makes the B4/5 neurons less effective). To evaluate the potential physiological significance of our results, we characterized B4/5 activity during the retraction phase of ingestive-like motor programs. This is a time when it has been hypothesized that B21 input to B8 is gated-in (rather than gated-out). We show that for most of the duration of retraction, the B4/5 neurons fire at a relatively low frequency. Additionally, B21 is phasically depolarized by central input. Simulations using SNNAP suggest that this pattern of activity will correspond to a brief period of high probability gating, followed by low probability gating for most of the duration of retraction. We verified that this was the case in experiments in which we monitored spike propagation in B21 when it was peripherally activated during motor programs induced by the command-like neuron CBI-2. We have, therefore, demonstrated that a well characterized mechanism that can gate-out afferent activity is present in an Aplysia preparation that is experimentally advantageous for studies of afferent transmission during physiologically defined motor programs. Data obtained in the present study indicate that the effectiveness of a gating neuron can change within a single cycle of a motor program.

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