Cooper et al. (1986) The effect of marathon running on carnitine metabolism and on some aspects of muscle mitochondrial activities and antioxidant mechanisms

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The effect of marathon running on carnitine metabolism and on some aspects of muscle mitochondrial activities and antioxidant mechanisms

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CONTRIBUTORS:

	Author:	Cooper, M. B.
	Author:	Jones, D. A.
	Author:	Edwards, R. H. T.
	Author:	Corbucci, G. C.
	Author:	Montanari, G.
	Author:	Trevisani, C.

JOURNAL:

Journal of Sports Sciences (JSS), ??( 4), ?? - ??.

YEAR:

1986

PUB TYPE:

Journal Article

SUBJECT(S):

TRACK-AND-FIELD; MARATHON; VITAMIN-B-COMPLEX; ADAPTATION; MAN; CYTOCHROME-OXIDASE

DISCIPLINE:

No discipline assigned

HTTP:

LANGUAGE:

English

PUB ID:

103-366-235 (Last edited on 2002/02/27 18:45:02 US/Mountain)

SPONSOR(S):

ABSTRACT:
Carnitine is an essential co-factor in the catabolism of fats as an energy source. The primary purpose of this study was to investigate the effect of running a marathon on the metabolism of carnitine by endurance-trained athletes, and to evaluate the effect of carnitine administration on the performance of such exercise. The effects of marathon running on mitochondrial enzymes and cellular anti-oxidants were also examined to assess whether the expression of these activities is altered by exercise. Subjects were 10 experienced male marathon runners aged between 19 and 25 years. Running a marathon caused a fall in the plasma content of unesterified carnitine (37 percent) and an increase in the level of acetylcarnitine present (288 percent). Loading of the athletes with L-carnitine for 10 days before running a marathon abolished the exercise-induced fall in plasma-free carnitine whilst amplifying the production of acetylcarnitine. Carnitine loading of the athletes studied made no detectable improvement in performance of the marathon. Cytochrome oxidase, succinate cytochrome C reductase and superoxide dismutase activities present in skeletal muscle were unaltered by marathon running. However, such exercise caused a large increase in the tissue content of oxidized glutathione (189 percent) at the expense of reduced glutathione (minus 18 percent).

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