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4 |
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844 |
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Dr. Laura S Frost
(b. ----,
d. ----)
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( Prev | Next )
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POSITION(S) / JOB TITLE(S):
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Professor |
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Bacterial conjugation was discovered over 50 years ago and was attributed to the F or fertility factor a few years later. Early research showed that the F factor was a plasmid that assembled long structures called pili which were essential for transferring DNA from bacterial cell to bacterial cell. These pili were also the site of attachment of many bacteriophages, the most notable being f1 and its relatives. This phage is the basis for many biotechnological applications including phage display which can be used to construct synthetic antibodies. Many systems turn out to be related to F conjugation including the process that gives rise to tumours in plants and the secretion of toxins and other virulence factors by many enteropathogenic bacteria. My lab is interested in the regulation of conjugative transfer at two levels: 1. what controls transfer gene expression in vegetatively growing cells? and 2. what allows the F+ cell to sense that the pilus has interacted with a recipient cell leading to the immediate replication of the DNA and transfer of a single strand to the recipient? A second project in the lab is understanding the structure of the pilus filament and its role in this signaling process. We are also using the pilus to display epitopes in a manner reminiscent of filamentous phages.
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Professor |
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Biological Sciences |
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University of Alberta |
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Only Visible to Members of getCITED
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Doctorate
(1978)
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University of Alberta
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Female / English
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Unknown |
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1107-0011
(Last changed on
2003/04/05 22:47:28)
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